Description
5D Communication – The 5th Dimension
The fifth dimension, we define as the communication of the cells with each other: the critically determined shape and size of the microwells create an environment that is as physiological as possible. Plus, a special nanocoating hinders cells from attaching to the surface. This results in the formation of uniform spheroids with an undisturbed communication of the cells with each other, preventing wrong signals that would induce unwanted gene expression/differentiation.
OUR TECHNOLOGY
- Physiological & easy spheroid formation by optimized niche geometry & surface
- Convenient upscaling without loss of spheroid quality
- Ability to translate into diagnostic or clinical use
Safety First
- Effortless upscaling of your cell spheroids without losing control over cell differentiation and spheroid size
- Medium change in your culture is rather simple and can be automated as well
- The safety profile of the SP5D reduces the risk of unintended tumorigenesis to a minimum which is a prerequisite for all translational approaches
Size and Space Matters
Due to our patented geometry:
- Precise control of spheroid size resulting in higher standardization & reproducibility
- High quantity of uniformly sized spheroids (9000/plate)
- Identical diffusion conditions for all spheroids
- Unique physiological spheroid formation with rounded bottoms
The Sphericalplate 5D allows the generation of uniform, size-controlled cell clusters needed for various research and diagnostic applications. Our platform enables the translation from bench to bedside and includes scalable, reliable and safe application of cell therapy. The SP5D has round-bottomed microwells and the surface is covered with high-end ultra-low attachment coating which allows for perfect cell aggregation. 3D cell culture protocols using the SP5D are highly scalable, as one plate can hold up 9000 spheroids. The scalable solutions on the market do not meet the required quality criteria for safe clinical use, therefore our SP5D closes this gap.