CytoSurge
CytoSurge is a pioneering biotechnology company known for its proprietary FluidFM technology, which combines microfluidics with force microscopy to enable non-destructive, nanoscale manipulation of single, living cells. Their solutions—such as the FluidFM OMNIUM platform and CellEDIT service—allow researchers to perform highly precise gene editing, cytoplasmic extractions, and mechanobiology studies without compromising cell viability.
Key Capabilities
- Live-Cell Biopsy & Profiling: Extract cytoplasmic content (such as mRNA) from individual living cells while keeping them fully viable. This allows for temporal RNA sequencing (Live-seq) of the exact same cell over time
- Intra-Nuclear CRISPR Delivery: Deliver CRISPR-Cas9 complexes directly into the cell nucleus without viral vectors. This maximizes editing efficiency, protects against cytosolic degradation, and minimizes off-target effect
- Single-Cell Force Spectroscopy: Quantify adhesion forces and study the mechanical properties (mechanobiology) of eukaryotic and microbial cells
- High-Precision Manipulation: Perform delicate tasks such as cell injection, extraction, and "pick and place" with sub-picoliter volume control
THE SAME CELL. BEFORE AND AFTER. From Single-Cell Biology to Same-Cell Biology Biology has traditionally relied on snapshots, measuring different cells at different moments and inferring causation from correlation. FluidFM®…