W8 Physical Cytometer: 3D spheroids

W8 Physical Cytometer: 3D spheroids

The W8 (pronounced ‘weight’) from Cell Dynamics is a physical cytomter for the quantitative measurement of size, weight and mass density for spherical biological samples. It can be used for 3D spheroids and spherical organoids  ranging from 50 microns to 500 microns.

Accurate and precise knowledge of mass density, shape, size and weight of spheroid like cells or cell aggregates provides valuable insights into understanding processes into outcomes for assays. Our early applications include cancer research, tissue engineering and regenerative medicine. The W8 physical cytometry system offers a paradigm shift by enabling standardisation of 3D heterogeneous models.

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Description

The W8 is a physical cytomter for the quantitative measurement of size, weight, and mass density of spherical biological material such as 3D spheroids and spherical organoids.

Gathering precise information on mass density, shape, size and weight of cells or cell aggregates, is crucial for several applications as for cancer research, tissue engineering and regenerative medicine. Although few technical solutions have been presented for single cell analysis, scientists still lack methods for physical cytometry and standardization of 3D Biology heterogenous models.

With an intuitive user Interface and automated data analysis in spreadsheet files, the W8 technology offers a groundbreaking weighing method to perform quality control of 3D cell culture and quantitatively evaluate in vitro assays from the physical point of view.

Specification

W8_AN_002-Harvesting-viable-spheroids-with-the-W8-Physical-Cytometer

W8_AN_001-A-label-free-biophysical-assay-for-QC-of-3D-cell-cultures

Literature

Brochure w8_2021_compressed

W8-DATASHEET-1

W8_MKT_012 Compatible tubes and plastic consumables[1]

W8_MKT_008 3D spheroids fixation with paraformaldehyde

W8_MKT_009 Guidelines for 3D cell culture shipment

Sargenti et al 2021_PlosOne

Sargenti_et_al-2020-Frontiers_in_Immunology

Cristaldi et al., 2020

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