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BioPen Systems

The BioPen is a microfluidic research tool which enables cell biologists to accurately and precisely add single or multiple reagents to individual cells or groups of cells without taking them out of their natural environment. This ground breaking tool which is already having tremendous impact in a number of applications including drug discovery, cancer research and new areas including mosquito research.

The BioPen is used in combination with existing hardware such as micromanipulators and microscopes. For inverted microscopes, we recommend the BioPen PRIME, for upright microscopes, we recommend the BioPen Flex.

BioPen® PRIME and BioPen® FLEX Systems are comprised of a high precision pressure controller, a disposable pipette tip inserted in a holder and, PC software. They integrate with common micromanipulators and microscopes.



A system contains:

1 – Disposable pipette tip: 

The pipette tip is used to deliver up to 4 different compounds. The pipette tip is made from a flexible medical grade elastomer material so that unlike glass pipettes it won’t break upon contact with a hard surface. It includes 8 wells; 4 wells for containing compounds and 4 wells for collecting waste. Each well can contain up to 35 μl of drugs. Two types of tips are available: PRIME and FLEX.

Discover BioPen PRIME and FLEX Pipette tips >>


2 – Pressure Controller:

Two levels of pneumatic pressure are supplied by the pressure controller and fast solution switching is achieved through the use of miniature solenoid valves.


3 – Pipette holder:

The pipette holder is a pressure manifold to assure a closed system and to connect each solution reservoir of the pipette tip individually with the precision pressure controller. It has been designed to be compatible with any standard type of micromanipulator such as, for example, the PatchStar from Scientifica. Two types of pipette holders are available: PRIME and FLEX.

Discover BioPen PRIME and FLEX Pipette Holders >>


4 – Software:

The software enables easy configuration and use of the BioPen® system. The Windows-based BioPen® software allows independent control of each pressure line and compounds delivery. It also includes a scripting module for automation of common tasks and setup/shutdown.


BioPen Applications

BioPen Brochure